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  Patronage of the Polish Society of Audiology and Phoniatrics

vol 4. no 4. December 2005  

 Review articles
The 2004 Nobel Prize: Discovery of the olfactory receptor genes
Leszek Białaczewski

The mammalian olfactory system can detect and discriminate a large variety of odor molecules. This sensory capacity of the nose has long been considered as a scientific mystery. Linda Buck and Richard Axel published the
fundamental paper in 1991. In that article they described the large multigene family of genes for olfactory receptors, which are seven-transmembrane domain G protein-coupled receptors. This landmark discovery elucidated the molecular and cellular mechanisms for the reception of odor molecules in the nose. The Nobel Assembly at Karolinska Institutet has decided to award The Nobel Prize in Physiology or Medicine for 2004 jointly to Richard Axel and Linda Buck for their research on odorant receptors and the organization of the olfactory
system. The purpose of this paper was to present the work of the prize winners that led to the isolation of olfactory receptor genes. The author described these genes, encoded receptors and signaling pathways consisting of
G protein activation and stimulation of adenyl cyclase.

keywords: geny receptorów węchowych, receptory węchowe, Nagroda Nobla, olfactory receptor genes, olfactory receptors, The Nobel Prize

pages: from 163 to 168

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