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  Patronage of the Polish Society of Audiology and Phoniatrics

vol 10. no 1. March 2011  

 Original articles
Estimation of CD3+CD69+ and CD3+HLA/DR+ antigens expression in whole blood T lymphocytes in patients with squamous cell laryngeal carcinoma
Katarzyna Starska, Olga Stasikowska, Iwona Lwy-Trenda, Paweł Papież, Jan Woś, Ewa Głowacka, Przemysłwa Lewkowicz

Introduction. During activation of cells involved in the cellular
immune response against tumor antigens, the stimulation markers
appear on the surface of the cells.
Aim. The aim of this study was to analyze the function of autologous
peripheral blood cells on the expression excitation of
markers of T lymphocytes in the patients with squamous cell
laryngeal carcinoma.
Material and methods. The analysis included a group of 55
patients with verified squamous cell carcinoma of the larynx.
The pTNM classifcation criteria, tumour histological grade and
tumour invasion have been included in the assay performed.
The expression of the stimulation markers in the blood cells of
patients was assessed using the techniques of immunofluorescence
labeling in whole blood.
Results. Increased expression of the early CD8/CD69 and
the late CD4/HLA/DR activation antigens on T lymphocytes in
peripheral blood of patients with carcinoma of the larynx was
an indicator of more advanced tumors evaluated on the basis
of pT characteristics.
Conclusions. The study indicates the importance of the estimation
of T lymphocytes activity as a biomarker of advanced
changes and progression of tumour in patients with laryngeal

keywords: rak krtani, antygen aktywacji CD3+CD69+, CD3+HLA/DR+, limfocyty T, laryngeal carcinoma, antigen of activation CD3+CD69+, CD3+HLA/DR+, T lymphocytes

pages: from 22 to 29

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