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  Authority of Polish Society of Allergology

vol 5. no 3. September 2000  

 Original articles
Concentration of IgE and lymphocyte B CD23+ in children with acute lymphoblastic leukemia after cessation of chemotherapy
Bogdan Mazur, Igor Olejnik, Danuta Sońta-Jakimczyk, Halina Bubała

The aim of study was the examination of the relative and absolute number of CD19+ and CD23+ B lymphocytes in peripheral vein blood and serum levels of immunoglobulin E in children with low risk acute lymphoblastic leukemia (ALL) diagnosis after cessation of chemotherapy. The lymphocyte immune phenotype was examined with FACScan flow cytometr using monoclonal antibodies. The examined material included 75 children with established ALL SGR diagnosis. All these children followed the BMF 90 for ALL SRG treatment protocol. The study confirmed that the intensive chemotherapy significantly decreases the absolute number of lymphocytes B CD10+ and CD23+, and level immunoglobulin E in serum. We conclude the period of 12 months after cessation of the chemotherapy is sufficient to recover the immune system function in all examined low risk ALL children.
Alergia Astma Immunologia, 2000, 5(3), 197-200

keywords: ostra białaczka limfoblastyczna, chemioterapia, limfocyty B, immunoglobulina E, acute lymphoblastic leukemia, chemoterapy, lymphocytes B, immunoglobulin E

pages: from 197 to 200

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