|Zbigniew Bartuzi, Bogdan Romański, Magdalena Żbikowska-Götz|
Katedra i Klinika Alergologii i Chorób Wewnętrznych Akademii Medycznej, ul.Ujejskiego 75, 85-168 Bydgoszcz
The aim of the present work was to determine the level of secretion of IL 5 in patients with food allergy and chronic gastritis ( both Helicobacter pylori positive and negative), together with an assessment of the degree of the eosinophil mucosal infiltration. The group of 34 patients with diagnosed food allergy was studied. All patients underwent gastroscopy, and had taken of the gastric mucosa (from the antral and duodenal regions taken). The presence of Helicobacter pylori was taken as either positive or negative. The levels of IL 5 in plasma were determined using ELISA.
Gastritis was confirmed in 32 of 34 studied samples. Helicobacter pylori was present in 18 of 32 studied samples. Eosinophil infiltration of the gastric mucosa was found in 24 of the 32 studied subjects. Raised levels of IL 5 were found in 23 of the 24 cases with eosinophil infiltrations and only 1 of the 8 with no infiltration.
It appears therefore that IL 5 influences the development of eosinophil infiltration caused by hypersensitive reaction of the mucosa to food and / or bacterial allergens in patients with Helicobacter pylori positive and negative gastritis.
pages: from 114 to 118
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