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Allergy Asthma Immunology
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Allergology Review

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  Authority of Polish Society of Allergology

vol 3. no 2. June 1998  

 Original articles
Diagnostic value of serum measurements of eosinophil cationic protein and myeloperoxidase in chidren with bronchial hyperresponsiveness
Alina Puchnarewicz, Jolanta Tobolczyk, Anna Płoszczuk, Jerzy Hofman

Zakład Alergologii Dziecięcej Akademii Medycznej, ul. J. Waszyngtona 17, 15-274 Białystok

Atopic bronchial asthma is a chronic inflammatory disease in which lymphocytes and eosinophils are involved. On the other hand reccurent bacterial infections bronchitis is associated with a bronchospastic component.
In this situation the "specific markers" for "allergic" and "non-allergic" inflammation was investigated. The aim of the study were the evaluate the relation between eosinophil cationic protein (ECP) the "marker of allergic response" and myeloperoxidase (MPO) the "marker of non-allergic response". The study included 47 children: 20 with chronic mild bronchial asthma (BA I), 10 with episodic atopic bronchial asthma (BA II) and 17 with recurrent infections of respiratory tract) (RIRT). Serum levels of ECP and MPO were determined by radioimmunoassay (RIA, Pharmacia). ECP level was significantly elevated in BA I and RIRT groups in comparison with control group, but without significant changes between BA I , BA II, and RIRT groups.
The MPO concentrations was significantly elevated in BA I and RIRT in comparison with control group, and the levels in RIRT group was significantly higher as compered to BA I and BA II groups. Our investigations showed that measuring ECP and MPO in serum only, are ansatisfactory criterions in diagnosis bronchospastic syndrom in children, and specificity of ECP as "allergic inflammation" and MPO as "non-specific marker" should be further investigated.


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