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Allergology Review

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  Authority of Polish Society of Allergology

vol 3. no 2. June 1998  

 Original articles
Sulphidoleukotrienes (sLT) release from leukocytes after stimulation with bee venom, bee venom's major allergen phospholipase A2 and inactivated phospholipase A2 in bee venom sensitive patients
Marita Nittner-Marszalska, Józef Małolepszy, Wojciech Mędrala, Irena Kustrzeba-Wójcicka

Klinika Chorób Wewnętrznych i Alergologii i Zakład Biochemii Akademii Medycznej, 50-417 Wrocław, ul. Traugutta 57

Phospholipase A2 is the major allergen in bee venom. Bee venom, native PLA2 and inactivated PLA2 were used in the CAST test in 11 bee venom sensitive patients and 10 control subjects. Compared with the control group, sLT4 production in the bee venom sensitive group was significantly higher after stimulation with bee venom (p=0.013), native PLA2 (p=0.009) and inactivated PLA2 (p=0.005). The CAST tests performed with bee venom, native PLA2 and inactivated PLA2 showed approximately similar specificity and sensibility. The results of CAST test in the study group point out to usefulness of PLA2 in the diagnosis of bee venom allergy.


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