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Allergy Asthma Immunology
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vol 3. no 3. winter 2006  

 Bronchial asthma
Molecular mechanisms of β2-adrenoreceptor agonists actions
Andrzej Obojski, Beata Chmielowicz

β2-adrenoreceptor is a member of membrane family receptors related to cAMP cascade. It is a long polypeptide passing the membrane seven times and forming characteristic intra and extra cellular loops. Activation of the β2-adrenoceptor results in adenylate cyclase activation and synthesis of intracellular secondary messenger –cAMP. Increase of cAMP concentration, through activation of protein kinases and protein phosphorylation, induces the change of cell activity. Short and long acting beta2 agonists (SABA and LABA) are key drugs used in the treatment of asthma and COPD (Chronic Obstructive Pulmonary Disease). Stimulation of beta2-adrenergic receptors in the respiratory tract leads to relaxation of airway smooth muscle, increase of mucociliary clearance and decrease of airway wall swelling.

keywords: receptor β2-adrenergiczny; mechanizm działania, β2-adrenoreceptor; mechanism of action

pages: from 22 to 25

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